Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and …

…, M Palkovits, G Faludi, MO Poulter, T Bédard… - Biological …, 2006 - Elsevier
BACKGROUND: Postmortem levels of several stress- and depression-relevant neuropeptides
were assessed in brain regions of depressed suicides relative to control subjects that had …

Bombesin receptors as a novel anti-anxiety therapeutic target: BB1 receptor actions on anxiety through alterations of serotonin activity

Z Merali, T Bédard, N Andrews, B Davis… - Journal of …, 2006 - Soc Neuroscience
The effects of PD 176252 [3-(1H-indol-3-yl)-N-[1-(5-methoxy-pyridin-2-yl)-cyclohexylmethyl]-2-methyl-2-[3-(nitro-phenyl)ureido]propionamide],
a nonpeptide bombesin (BB) BB 1 /BB 2 …

Role of gastrin-releasing peptide and neuromedin B in anxiety and fear-related behavior

T Bédard, C Mountney, P Kent, H Anisman… - Behavioural brain …, 2007 - Elsevier
Bombesin (BB)-like peptides have been implicated in the mediation and/or modulation of
the stress response. However, the impact of manipulating this peptidergic system has only …

Prevalence of multiple congenital contractures including arthrogryposis multiplex congenita in Alberta, Canada, and a strategy for classification and coding

RB Lowry, B Sibbald, T Bedard… - Birth Defects Research …, 2010 - Wiley Online Library
BACKGROUND The population prevalence of multiple congenital contractures, many of
which have either arthrogryposis multiplex congenita or amyoplasia congenita, ranges from 1/…

International multidisciplinary collaboration toward an annotated definition of arthrogryposis multiplex congenita

…, S Cachecho, D Barnes, T Bedard… - American Journal of …, 2019 - Wiley Online Library
Arthrogryposis multiplex congenita (AMC) has been described and defined in thousands of
articles, but the terminology used has been inconsistent in clinical and research communities…

Changes in frequencies of select congenital anomalies since the onset of folic acid fortification in a Canadian birth defect registry

KA Godwin, B Sibbald, T Bedard, B Kuzeljevic… - Canadian journal of …, 2008 - Springer
Objectives Fortification of grain products with folic acid has been shown to significantly
reduce the occurrence of neural tube defects (NTDs) in Canada and elsewhere. However, the …

Behavioural assays to model cognitive and affective dimensions of depression and anxiety in rats

…, GA Rodriguez, T Bédard‐Arana… - Journal of …, 2008 - Wiley Online Library
Animal models have been used extensively to investigate neuropsychiatric disorders, such
as depression, and their treatment. However, the aetiology and pathophysiology of many …

Noradrenergic facilitation of shock-probe defensive burying in lateral septum of rats, and modulation by chronic treatment with desipramine

CO Bondi, G Barrera, MDS Lapiz, T Bedard… - Progress in Neuro …, 2007 - Elsevier
We have previously shown that acute stress-induced release of norepinephrine (NE) facilitates
anxiety-like behavioral responses to stress, such as reduction in open-arm exploration on …

Congenital limb deficiencies in Alberta—a review of 33 years (1980–2012) from the Alberta Congenital Anomalies Surveillance System (ACASS)

T Bedard, RB Lowry, B Sibbald… - American journal of …, 2015 - Wiley Online Library
The birth prevalence of limb deficiencies in Alberta has been fluctuating. The objectives
were to examine patterns and temporal trends of congenital limb deficiencies in Alberta and …

Neither acute nor chronic exposure to a naturalistic (predator) stressor influences the interleukin-1β system, tumor necrosis factor-α, transforming growth factor-β1, and …

…, SE Ilyin, NP Turrin, D Gayle, MC Flynn, T Bedard… - Brain research …, 2000 - Elsevier
Physical (neurogenic) stressors may influence immune functioning and interleukin-1β (IL-1β)
mRNA levels within several brain regions. The present study assessed the effects of an …