Background. A dysfunctional differentiation between self-relevant and irrelevant information
may affect the perception of environmental stimuli as abnormally salient. The aberrant …

Increased striatal dopamine synthesis capacity has consistently been reported in patients
with schizophrenia. However, the mechanism translating this into behavior and symptoms …

Recent theories of cortical function construe the brain as performing hierarchical Bayesian
inference. According to these theories, the precision of prediction errors plays a key role in …

Background Reward-based decision making is impaired in patients with schizophrenia (PSZ),
as reflected by increased choice switching. The underlying cognitive and motivational …

The striatum is known to play a key role in reinforcement learning, specifically in the encoding
of teaching signals such as reward prediction errors (RPEs). It has been proposed that …

To understand the dysfunctional mechanisms underlying maladaptive reasoning of psychosis,
computational models of decision making have widely been applied over the past decade…

Alterations in belief updating are proposed to underpin symptoms of psychiatric illness,
including psychosis, depression, and anxiety. Key parameters underlying belief updating can be …

Background To date, there is no systematic overview of glutamate in the dorsolateral
prefrontal cortex (DLPFC) of patients with schizophrenia. Here, we meta-analyzed case-control …

Background Cognitive deficits such as working memory (WM) impairment are core features
of schizophrenia. One candidate marker for the integrity of synaptic neurotransmission …

Appetitive Pavlovian conditioning is a learning mechanism of fundamental biological and
pathophysiological significance. Nonetheless, its exploration in humans remains sparse, which …