Stressful events during adulthood are potent adverse environmental factors that can predispose
individuals to psychiatric disorders, including depression; however, many individuals …

There is growing evidence suggesting that early life events have long-term effects on the
neuroendocrine and behavioral developments of rodents. However, little is known about the …

Background Although depression is the leading cause of disability worldwide, its pathophysiology
is poorly understood. Recent evidence has suggested that sirtuins (SIRTs) play a key …

Chromatin remodeling such as changes in histone acetylation has been suggested to play an
important role in the pathophysiology and treatment of mood disorders. In the present study…

Chronic stress-induced aberrant gene expression in the brain and subsequent dysfunctional
neuronal plasticity have been implicated in the etiology and pathophysiology of mood …

Sirtuins are a family of NAD+-dependent enzymes that regulate cellular functions through
deacetylation of various proteins. Although recent reports have suggested an important role of …

Aberrant transcriptional regulation in the brain is thought to be one of the key components of
the pathogenesis and pathophysiology of neuropsychiatric disorders. Heat shock factors (…

Aberrant transcriptional regulation may be one of the key components of the pathophysiology
of mood disorders. DNA methylation generally acts as an epigenetic gene silencing …

Recent studies suggest that the dysfunction of neural plasticity is associated with mood
disorders. Hypoxia-inducible factor-1 (HIF-1), which is a transcriptional activator of vascular …

Background Depression in old age is an increasing contributor to poor health and accompanying
health care costs. Although there is an abundance of literature on later-life depression (…