The current research paradigm for Huntington's disease is based on participants with overt
clinical phenotypes and does not address its pathophysiology nor the biomarker changes …

Obtaining reliable longitudinal information about everyday functioning from individuals with
Parkinson's disease (PD) in natural environments is critical for clinical care and research. …

Background Cognitive impairment is a common nonmotor manifestation of Parkinson's disease,
with deficits ranging from mild cognitive difficulties in 1 or more of the cognitive domains …

Background The study of complex neurodegenerative diseases is moving away from
hypothesis‐driven biological methods toward large scale multimodal approaches, requiring …

Background Essential tremor is one of the most prevalent movement disorders. Many
treatments for essential tremor have been reported in clinical practice, but it is uncertain which …

Disease staging is an important tool in both clinical research and medical practice because
it allows for an unequivocal allocation of individuals into groups of shared biomedical …

Background: In Parkinson’s disease (PD), there is heterogeneity in the clinical presentation
and underlying biology. Research on PD subtypes aims to understand this heterogeneity …

Subthalamic nucleus deep brain stimulation (STN‐DBS) has revolutionized the management
of disabling motor complications in Parkinson's disease. The EARLYSTIM trial applied this …

Background Despite the effectiveness of levodopa for treatment of Parkinson’s disease (PD),
prolonged usage leads to development of motor complications, most notably levodopa-…

Deep brain stimulation (DBS) is a well‐established treatment option for movement disorders,
especially for Parkinson's disease (PD). There is a need to determine the role of …