Classical benzodiazepine drugs are in wide clinical use as anxiolytics, hypnotics, anticonvulsants,
and muscle relaxants. They act by enhancing the γ-aminobutyric acid A (GABA A ) …

Although general anaesthesia has been of tremendous importance for the development of
surgery, the underlying mechanisms by which this state is achieved are only just beginning to …

GABA A (γ-aminobutyric acid, type A) receptors are a family of ligand-gated ion channels
that are essential for the regulation of central nervous system function. Benzodiazepines — …

… The latency for reentering the dark compartment 24 h later was shortened in wildtype (U
¼ 16.5, P 0.01 compared with vehicle) but not in 1(H101R) mice (U ¼ 48.0, ns) (Fig. 3b). In a …

Benzodiazepine tranquilizers are used in the treatment of anxiety disorders. To identify the
molecular and neuronal target mediating the anxiolytic action of benzodiazepines, we …

The heterogeneity of γ-aminobutyric acid type A (GABA A ) receptors contributes to the diversity
of neuronal inhibition in the regulation of information processing. Although most GABA A …

Background Due to the SARS-CoV2 pandemic, medical face masks are widely recommended
for a large number of individuals and long durations. The effect of wearing a surgical and …

General anesthetics are widely used in clinical practice. On the molecular level, these compounds
have been shown to modulate the activity of various neuronal ion channels. However, …

Inflammatory diseases and neuropathic insults are frequently accompanied by severe and
debilitating pain, which can become chronic and often unresponsive to conventional …

GABA A receptors are molecular substrates for the regulation of vigilance, anxiety, muscle
tension, epileptogenic activity, and memory functions, and the enhancement of GABA A …