Insufficient default mode network (DMN) suppression was linked to increased rumination in
symptomatic Major Depressive Disorder (MDD). Since rumination is known to predict relapse …

Objective: Clinical trials demonstrated that ketamine exhibits rapid antidepressant efficacy
when administered in subanaesthetic dosages. We reviewed currently available literature …

Hippocampal volume loss has been related to chronic stress as well as genetic factors.
Although genetic and environmental variables affecting hippocampal volume have extensively …

Mood disorders are highly heritable and have been linked to brain regions of emotion
processing. Over the past few years, an enormous amount of imaging genetics studies has …

Background Early‐onset (EO) major depressive disorder (MDD) patients experience more
depressive episodes and an increased risk of relapse. Thus, on a neurobiological level, adult …

This multicenter, cross-sectional study with retrospective assessment of treatment response
evaluated the current prescription trends and pharmacological treatment strategies applied …

Due to lacking predictors of depression recovery, successful treatment of major depressive
disorder (MDD) is frequently only achieved after therapeutic optimization leading to a …

Schizophrenia is characterized by increased behavioral and neurochemical responses to
dopamine-releasing drugs. This prompted the hypothesis of psychosis as a state of “…

Prefrontal dopamine levels are relatively increased in adolescence compared to adulthood.
Genetic variation of COMT (COMT Val158Met) results in lower enzymatic activity and higher …

The coronavirus disease 2019 (COVID-19) pandemic led to increased psychological distress
and far-reaching restrictions of freedom. In March 2020, Austrian penal authorities enacted …