In this review we will critically assess the hypothesis that the reinforcing effect of virtually all
drugs of abuse is primarily dependent on activation of the mesolimbic dopamine system. The …

Increases in dopamine and glutamate transmission in the nucleus accumbens independently
promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have …

Cocaine self-administration alters patterns of gene expression in the brain that may underlie
cocaine-induced neuronal plasticity. In the present study, male Sprague Dawley rats were …

Accumulating evidence suggests that metabotropic glutamate receptors (mGluRs) are involved
in both cocaine reinforcement and the reinstatement of cocaine-seeking behavior. In the …

Cocaine addiction in human addicts is characterized by a high rate of relapse following
successful detoxification. Relapse to drug taking/seeking can be precipitated by several stimuli …

A growing body of evidence indicates that enhanced AMPA-mediated glutamate
transmission in the core of the nucleus accumbens is critically involved in cocaine priming-induced …

Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric
disorders; however, the basic underlying mechanisms of memory and altered states of circuitry …

Cocaine administration alters the microRNA (miRNA) landscape in the cortico-accumbal
pathway. These changes in miRNA can play a major role in the posttranscriptional regulation of …

Decades of research attempting to slow the onset of Alzheimer's disease (AD) indicates that
a better understanding of memory will be key to the discovery of effective therapeutic …

Traffic safety analyses have historically been used by transportation officials as a means to
reduce the impact of traffic crashes on roadways. This paper summarizes the methodology to …