Cognitive deficits are a core feature across psychiatric disorders. Emerging evidence indicates
that metabolic pathways are highly relevant for the substrates and phenomenology of the …

Background Most psychiatric disorders emerge in the second decade of life. In the present
study, we examined whether environmental adversity, developmental antecedents, major …

The traditional view of the medial temporal lobe (MTL) focuses on its role in episodic memory.
However, some of the underlying functions of the MTL can be ascertained from its wider …

Background Attention‐deficit/hyperactivity disorder (ADHD) and lower cognitive ability have
been linked with increased likelihood of exposure to adversity. We hypothesized that these …

BackgroundPsychotic symptoms are common in children and adolescents and may be early
manifestations of liability to severe mental illness (SMI), including schizophrenia. SMI and …

Affective lability, defined as the propensity to experience excessive and unpredictable changes
in mood, has been proposed as a potential transdiagnostic predictor of major mood and …

Background It has been suggested that offspring of parents with bipolar disorder are at
increased risk for disruptive mood dysregulation disorder (DMDD), but the specificity of this …

Background: Cortical folding is essential for healthy brain development. Previous studies
have found regional reductions in cortical folding in adult patients with psychotic illness. It is …

Introduction A new generation of large‐scale studies is using neuroimaging to investigate
adolescent brain development across health and disease. However, imaging artifacts such as …

BackgroundBasic symptoms, defined as subjectively perceived disturbances in thought,
perception and other essential mental processes, have been established as a predictor of …