Cocaine-induced alterations in gene expression cause changes in neuronal morphology
and behavior that may underlie cocaine addiction. In mice, we identified an essential role for …

Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such
as palatable food, sexual activity and social interaction) and modulates the rewarding effects …

Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation
and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a …

Objective: Despite the staggering consequences of the opioid epidemic, limited nonopioid
medication options have been developed to treat this medical and public health crisis. This …

The Stanford–Lancet Commission on the North American Opioid Crisis was formed in response
to soaring opioid-related morbidity and mortality in the USA and Canada over the past …

In the present study, estrogen receptor (ER)α and ERβ genes were found to be differentially
expressed in discrete subregions of the rat amygdaloid complex. The amygdala nuclei …

Substance P exerts its various biochemical effects mainly via interactions through neurokinin‐1
receptors (NK1). Recently, the NK1 receptor has attracted considerable interest for its …

Endocannabinoids (eCBs) have recently been identified as axon guidance cues shaping
the connectivity of local GABAergic interneurons in the developing cerebrum. However, eCB …

Molecular changes in the neostriatum of human subjects who died with a history of cocaine
abuse were revealed in discrete cell populations by means of the techniques of in situ …

Estrogen has been shown to influence several brain functions as well as the expression of
neuropsychiatric diseases. To date, two estrogen receptor (ER) subtypes have been identified…