Animals susceptible to chronic social defeat stress (CSDS) exhibit depression-related
behaviors, with aberrant transcription across several limbic brain regions, most notably in the …

Major depressive disorder (MDD) is the leading cause of disability worldwide. There is an
urgent need for objective biomarkers to diagnose this highly heterogeneous syndrome, assign …

Depression is a common disorder that affects women at twice the rate of men. Here, we report
that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory transcripts…

Women suffer from depression at twice the rate of men, but the underlying molecular
mechanisms are poorly understood. Here, we identify marked baseline sex differences in the …

Background Major depressive disorder is a pervasive and debilitating syndrome characterized
by mood disturbances, anhedonia, and alterations in cognition. While the prevalence of …

Background The onset and persistence of addiction phenotypes are, in part, mediated by
transcriptional mechanisms in the brain that affect gene expression and, subsequently, neural …

Cocaine use disorder is a significant public health issue without an effective pharmacological
treatment. Successful treatments are hindered in part by an incomplete understanding of …

… Bagot a , Orna Issler a , Yentl Van der Zee a , Andrew P. Lipschultz a , Arthur Godino a , …
Genes on the X and Y chromosomes are highlighted on these heatmaps to verify that sex …

Adolescence is a sensitive window for reward- and stress-associated behavior. Although
stress during this period causes long-term changes in behavior in males, how females respond …

A hallmark of addiction is the ability of drugs of abuse to trigger relapse after periods of
prolonged abstinence. Here, we describe a novel epigenetic mechanism whereby chronic …