The hippocampus is vulnerable to the damaging actions of insults such as transient ischemia
and repetitive stimulation, as well as repeated exposure to exogenous glucocorticoids. …

Wolfram (DIDMOAD) syndrome is an autosomal recessive neurodegenerative disorder
accompanied by insulin-dependent diabetes mellitus and progressive optic atrophy. Recent …

Stressful events during adulthood are potent adverse environmental factors that can predispose
individuals to psychiatric disorders, including depression; however, many individuals …

Repeated daily restraint stress and daily corticosterone administration to adult male
Sprague‐Dawley rats leads to decreases in the number of branch points and length of dendrites of …

Repeated 6-h daily restraint stress over 21 days reduces length and number of branch points
of hippocampal CA3c pyramidal dendrites in the hippocampal formation of adult male rats. …

The effects of chronic and acute corticosterone (CORT) administration were investigated on
hippocampal long‐term potentiation (LTP) in the dentate gyrus granule cell layer of the rat. …

There is growing evidence suggesting that early life events have long-term effects on the
neuroendocrine and behavioral developments of rodents. However, little is known about the …

In the present study, we established and characterized an animal model of vulnerability to
repeated stress. We found that control Sprague–Dawley (SD) rats showed a gradual decrease …

Background Although depression is the leading cause of disability worldwide, its pathophysiology
is poorly understood. Recent evidence has suggested that sirtuins (SIRTs) play a key …

Chromatin remodeling such as changes in histone acetylation has been suggested to play an
important role in the pathophysiology and treatment of mood disorders. In the present study…