Somatic mutations of the mitochondrial genome in human colorectal tumours

K Polyak, Y Li, H Zhu, C Lengauer, JKV Willson… - Nature …, 1998 - nature.com
Alterations of oxidative phosphorylation in tumour cells were originally believed to have a
causative role in cancerous growth 1. More recently, mitochondria have again received …

[HTML][HTML] Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular …

Y Li, H Zhu, P Kuppusamy, V Roubaud… - Journal of Biological …, 1998 - ASBMB
Lucigenin is most noted for its wide use as a chemiluminescent detector of superoxide
anion radical (O·̄ 2 ) production by biological systems. However, its validity as a O·̄ 2 -detecting …

Diphenyleneiodonium, an NAD (P) H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production

Y Li, MA Trush - Biochemical and biophysical research communications, 1998 - Elsevier
Diphenyleneiodonium (DPI) has frequently been used to inhibit reactive oxygen species (ROS)
production mediated by flavoenzymes, particularly NAD(P)H oxidase. This study was …

Mitochondrial adaptations to obesity-related oxidant stress

SQ Yang, H Zhu, Y Li, HZ Lin, K Gabrielson… - Archives of biochemistry …, 2000 - Elsevier
It is not known why viable hepatocytes in fatty livers are vulnerable to necrosis, but associated
mitochondrial alterations suggest that reactive oxygen species (ROS) production may be …

[HTML][HTML] Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species …

H Zhu, K Itoh, M Yamamoto, JL Zweier, Y Li - FEBS letters, 2005 - Elsevier
Understanding the molecular pathway(s) of antioxidant gene regulation is of crucial
importance for developing antioxidant-inducing agents for the intervention of oxidative cardiac …

Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection …

Y Li, Z Cao, H Zhu - Pharmacological research, 2006 - Elsevier
Resveratrol (3,4′,5-trihydroxystilbene), a polyphenolic compound found in mulberries,
grapes and red wine has been demonstrated to be capable of protecting against oxidative …

Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury

Z Cao, Y Li - European journal of pharmacology, 2004 - Elsevier
Resveratrol is known to be protective against oxidative cardiovascular disorders. However,
the underlying mechanisms remain unclear. This study was undertaken to determine if …

Reactive oxygen-dependent DNA damage resulting from the oxidation of phenolic compounds by a copper-redox cycle mechanism

Y Li, MA Trush - Cancer research, 1994 - AACR
Recently, copper has been shown to be capable of mediating the activation of several
xenobiotics producing reactive oxygen and other radicals. Since copper exists in the nucleus and …

DNA damage resulting from the oxidation of hydroquinone by copper: role for a Cu (II)/Cu (I) redox cycle and reactive oxygen generation

Y Li, MA Trush - Carcinogenesis, 1993 - academic.oup.com
The myelotoxicity, including leukemia, associated with benzene exposure has been attributed
to the further activation of benzene-derived metabolites. In a previous study, we observed …

Modification of the Intermediate Binding Energies on Ni/Ni3N Heterostructure for Enhanced Alkaline Hydrogen Oxidation Reaction

L Su, D Gong, N Yao, Y Li, Z Li… - Advanced Functional …, 2021 - Wiley Online Library
Developing highly efficient and stable non‐precious metal‐based electrocatalysts for
alkaline hydrogen oxidation reaction (HOR) is essential for the commercialization of alkaline …