Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A …

H Sato, I Skelin, G Debonnel, M Diksic - Brain Research Bulletin, 2008 - Elsevier
The olfactory bulbectomized (OBX) rat model of depression has been widely used in studies
on the behavioral and neurochemical aspects of human depression. The objective of the …

Effects of acute and sustained administration of vilazodone (EMD68843) on monoaminergic systems: an in vivo electrophysiological study

A Crnic - 2014 - ruor.uottawa.ca
Vilazodone is a partial 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor
(SSRI). Acute administration caused a dose-dependent decrease in dorsal raphe (DR) …

Current treatment options: relief of symptoms and ultimate recovery

SH Kennedy - International Journal of Psychiatry in Clinical …, 2006 - Taylor & Francis
The inadequate outcome of existing antidepressant therapies has led to a shift in the
expectations of optimal treatment toward remission rather than response. Important …