Increased rostral anterior cingulate cortex (rACC) activity has emerged as a promising
predictor of treatment response in depression, but neither the reliability of this relationship …

Introduction The heterogeneity of symptoms and complex etiology of depression pose a
significant challenge to the personalization of treatment. Meanwhile, the current application …

In the last decade the serotonin transporter gene promoter polymorphism (5-HTTLPR) was
likely the most studied genetic variant as predictor of antidepressant response. Nevertheless …

Context The need for improved therapeutic agents that more quickly and effectively treat
depression is critical. In a pilot study we evaluated the role of the cholinergic system in …

Up to one third of patients adequately treated for Major Depressive Disorder (MDD) do not
respond to multiple interventions. Many studies investigated predictors in MDD outcome, but …

BACKGROUND: We previously reported that intravenous (IV) scopolamine administration
produced rapid and robust antidepressant effects in a sample consisting of both unipolar …

Background The duration of untreated depression (DUD) might have a substantial impact on
the clinical outcomes; however, there are important knowledge gaps including the effects on …

BACKGROUND: The application of rTMS in Depression has been very well investigated
over the last few years. However, little is known about predictors of non-response associated …

Background Although approximately half of adults diagnosed with a depressive or anxiety
disorder exhibit their simultaneous co-occurrence, traditional research has centered on …

This book provides a comprehensive review of melancholia as a severe disorder of mood,
associated with suicide, psychosis, and catatonia. The syndrome is defined with a clear …