Anhedonia is considered a core feature of major depressive disorder, and the dopamine
system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic …

Current management of major depression, a common and debilitating disorder with a high
social and personal cost, is far from satisfactory. All available antidepressants act through …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The monoamine hypothesis has been the prevailing hypothesis of depression over the last
several decades. It states that depression is associated with reduced monoamine function …

Benzodiazepine sedative‐hypnotic drugs are widely used for the treatment of insomnia.
Nevertheless, their adverse effects, such as next‐day hangover, dependence and …

Major depressive disorder (MDD), also known as unipolar depression, is one of the leading
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …

Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …

The efficacy and safety of flexible dosing with the antidepressant agomelatine (25–50
mg/day) was evaluated in a 6-week, double-blind, randomized, placebo-controlled study …

BACKGROUND: Antidepressant treatments increase neural plasticity and adult
neurogenesis, especially in the hippocampus. Here, we determined the effects of …

Background: Melatonin (MLT) is a pleiotropic neurohormone controlling many physiological
processes and whose dysfunction may contribute to several different diseases, such as …