The inadequacy of a categorial approach to mental health diagnosis is now well-recognised,
with many authors, diagnostic manuals and funding bodies advocating a dimensional, trans …

Interoceptive sensitivity, particularly regarding heartbeat, has been suggested to play a
pivotal role in the pathogenesis of anxiety and anxiety disorders. This review provides an …

Prepulse inhibition (PPI) is a robust operational measure of sensorimotor gating. In
schizophrenic patients PPI is deficient. The aim of our review was to investigate the state of …

The central and autonomic nervous systems can be defined by their anatomical, functional
and neurochemical characteristics, but neither functions in isolation. For example …

Corticotropin-releasing factor (CRF) and the related urocortin peptides mediate behavioral,
cognitive, autonomic, neuroendocrine and immunologic responses to aversive stimuli by …

Behavioral phenotyping has been gaining prominence due to the increased use of
transgenic animal models of neurological disorders. Repeated testing in the same cohort of …

The biological functions debate is a perennial topic in the philosophy of science. In the first
full-length account of the nature and importance of biological functions for many years …

Some theories of emotion emphasise a close relationship between interoception and
subjective experiences of emotion. In this study, we used facial expressions to examine …

Animal models of anxiety disorders are important for elucidating neurobiological defense
mechanisms. However, animal models are limited when it comes to understanding the more …

Abnormalities in the simplest form of learning, habituation, have been reported in a variety of
neuropsychiatric disorders as etiologically diverse as Autism Spectrum Disorder, Fragile X …