Schizophrenia is a major psychiatric disorder that lacks a unifying neuropathology, while
currently available pharmacological treatments provide only limited benefits to many …

Background Insulin is a critical component of metabolic control, and as such, insulin gene
expression has been the focus of extensive study. DNA sequences that regulate …

Dysfunction of prefrontal cortex in schizophrenia includes changes in GABAergic mRNAs,
including decreased expression of GAD1, encoding the 67 kDa glutamate decarboxylase …

Lagali PS, Corcoran CP, Picketts DJ. Hippocampus development and function: role of
epigenetic factors and implications for cognitive disease. The hippocampus is a primary …

Histone deactylase enzymes are responsible for the deacetylation of histone tails, and
consequently influence gene regulation through their ability to modify chromatin structure …

Many cellular constituents in the human brain permanently exit from the cell cycle during pre-
or early postnatal development, but little is known about epigenetic regulation of neuronal …

Levels of acetylated Histone 3 and 4 proteins are strongly predictive of a chromatin structure
that is conducive to gene expression. In cell and animal studies, valproic acid is a potent …

Global alterations in gene expression have been observed in different traumatic brain injury
(TBI) models and are considered of crucial importance to the development of subsequent …

The impact of epigenetic modifications like DNA methylation on plant phenotypes has
expanded the possibilities for crop development. DNA methylation plays a part in the …

Stroke is a significant cause of death and long-term disability in the USA. The incidence,
mortality, and outcomes of stroke are significantly different between men and women. As …