Mood disorders are common and debilitating, resulting in a significant public health burden.
Current treatments are only partly effective and patients who have failed to respond to trials …

Background Lamotrigine is not recommended in the prevention of migraine in general but
some reports suggest that it might be effective for treating specifically migraine with aura …

We investigated the effects of lamotrigine, aripiprazole and escitalopram administration and
experimental depression on lipid peroxidation (LP) and antioxidant levels in cortex of the …

The present behavioural investigation evaluates the antidepressant potential of ondansetron
(OND), a widely used (in management of cancer chemotherapy-induced nausea and …

Aim Capric acid (also known as decanoic acid or C10) is one of the fatty acids in the medium‐
chain triglycerides (MCTs) commonly found in dietary fats. Although dietary treatment with …

HT1A receptors are key components of the serotonin system, acting both pre-and post-
synaptically in different brain areas. There is a growing amount of evidence showing the …

Lamotrigine is an anticonvulsant agent that shows clinical antidepressant properties. The
aim of the present study was to investigate the involvement of N-methyl-d-aspartate (NMDA) …

Abstract Phosphodiesterase 4 (PDE4) has four isoforms (PDE4A-D) with at least 25 splice
variants. PDE4 subtype nonselective inhibitors produce potent antidepressant-like and …

Preclinical and clinical studies indicate that deficiency in folic acid plays a role in the
pathophysiology of depression. Considering that alterations in the signaling pathways that …

Lamotrigine is an anticonvulsant drug that is also effective in the treatment of mood
disorders, especially bipolar disorder. However, few studies have been conducted in animal …