Background: Modafinil is a novel wakepromoting agent that has US Food and Drug
Administration approval for narcolepsy and shift work sleep disorder and as adjunctive …

Background: The use of light for its antidepressant action dates back to the beginnings of
civilization. Three decades ago, the use of bright-light therapy (BLT) for treating Seasonal …

Light therapy'is established worldwide as the treatment of choice for seasonal affective
disorder. It is also successfuly used in nonseasonal depression, as well as for many other …

In addition to its role in vision, light exerts strong effects on behavior. Its powerful role in the
modulation of mood is well established, yet remains poorly understood. Much research has …

Fatigue and sleepiness (hypersomnia) are symptoms that are highly prevalent in patients
with major depressive disorder (MDD). Individuals who complain of fatigue but do not have …

Sleep deprivation (SD) is a powerful antidepressant treatment that shows antidepressant
responses within hours in 40–60% of depressed patients. In more than 80% of responders …

Ketamine, a drug with rapid antidepressant effects and well-described effects on slow wave
sleep (SWS), is a useful intervention for investigating sleep–wake mechanisms involved in …

There is an urgent need for rapid, effective, and safe treatments for bipolar depression.
Triple chronotherapy is a combination of sleep deprivation, sleep phase advance, and bright …

Introduction: Bipolar disorder is a psychiatric illness with recurring episodes of mania and
depression. Armodafinil, the R-enantiomer of modafinil, approved for treating excessive …

Chronotherapeutic interventions (CTs) produce rapid antidepressant effects and, when
applied sequentially, maintain an enduring antidepressant response following the initial CT …