Naltrexone (NTX) has been widely studied for the treatment of alcohol use disorder with
overall support for its efficacy. The mechanisms of action of naltrexone are thought to involve …

This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

There is significant experimental evidence implicating the endogenous opioid system
(opioid peptides and opioid receptors) with the processes of reward and reinforcement …

Background: The endogenous opioid system plays a significant role in alcohol dependence.
The goal of the current study was to investigate regional brain mu‐opioid receptor (MOR) …

Ethanol increases the interstitial dopamine (DA) concentration in the nucleus accumbens
(NAcc) of experimental animals, but positron emission tomography (PET) studies using the …

Background: Few pharmacological treatments for alcohol dependence are available.
Moreover, the best supported treatment, naltrexone hydrochloride, appears to work for only …

Intoxicated aggression is both a dangerous and a costly problem for society, with alcohol
being involved in over 50% of violent crimes, and the cost of alcohol-consumption-related …

Rationale There is evidence to suggest that individual differences in the subjective response
to alcohol exist and exaggerated cardiac response to alcohol has been suggested to be a …

Background: Despite the fact that adolescent rats have repeatedly been found to consume
more ethanol than adult rats in a variety of ethanol access paradigms, the exact cause of the …

Athough the exact cause of the increase in ethanol consumption during adolescence is not
known, age differences in sensitivity to some of ethanol's effects may play a contributory role …