[HTML][HTML] The serotonin theory of depression: a systematic umbrella review of the evidence

J Moncrieff, RE Cooper, T Stockmann… - Molecular …, 2023 - nature.com
The serotonin hypothesis of depression is still influential. We aimed to synthesise and
evaluate evidence on whether depression is associated with lowered serotonin …

[HTML][HTML] Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: update 2017

C Hiemke, N Bergemann, HW Clement… - …, 2018 - thieme-connect.com
Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Neural mechanisms of the cognitive model of depression

SG Disner, CG Beevers, EAP Haigh… - Nature Reviews …, 2011 - nature.com
In the 40 years since Aaron Beck first proposed his cognitive model of depression, the
elements of this model—biased attention, biased processing, biased thoughts and …

[HTML][HTML] AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011

C Hiemke, P Baumann, N Bergemann… - …, 2011 - thieme-connect.com
Therapeutic drug monitoring (TDM), ie, the quantification of serum or plasma concentrations
of medications for dose optimization, has proven a valuable tool for the patient-matched …

SLC6 neurotransmitter transporters: structure, function, and regulation

AS Kristensen, J Andersen, TN Jørgensen… - Pharmacological …, 2011 - ASPET
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

[HTML][HTML] A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression

S Jauhar, D Arnone, DS Baldwin, M Bloomfield… - Molecular …, 2023 - nature.com
A recent “umbrella” review examined various biomarkers relating to the serotonin system,
and concluded there was no consistent evidence implicating serotonin in the …

[PDF][PDF] Neurobiology of depression, fibromyalgia and neuropathic pain

V Raison - Front Biosci, 2009 - researchgate.net
[Frontiers in Bioscience 14, 5291-5338, June 1, 2009] 5291 Neurobiology of depression,
fibromyalgia and neuropathic pain Vladimi Page 1 [Frontiers in Bioscience 14, 5291-5338, June …

Revisiting the serotonin hypothesis: implications for major depressive disorders

M Fakhoury - Molecular neurobiology, 2016 - Springer
Major depressive disorder (MDD) is a heritable neuropsychiatric disease associated with
severe changes at cellular and molecular levels. Its diagnosis mainly relies on the …

Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder

A Mørk, A Pehrson, LT Brennum, SM Nielsen… - … of Pharmacology and …, 2012 - ASPET
1-[2-(2, 4-Dimethylphenyl-sulfanyl)-phenyl]-piperazine (Lu AA21004) is a human (h)
serotonin (5-HT) 3A receptor antagonist (Ki= 3.7 nM), h5-HT7 receptor antagonist (K i= 19 …

Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease

SJ Kish, J Tong, O Hornykiewicz, A Rajput, LJ Chang… - Brain, 2008 - academic.oup.com
Interest in serotonergic involvement in Parkinson's disease (PD) has focussed recently on
the possibility that the remaining serotonin neurons innervating striatum (caudate and …