Although the early antidepressant trials which included severely ill and hospitalized patients
showed substantial drug‐placebo differences, these robust differences have not held up in …

Background: clozapine (CLZ) use is precarious due to its neurological, cardiovascular, and
hematological side effects; however, it is the gold standard in therapy-resistant …

Dr. Joel Paris' Overdiagnosis in Psychiatry takes a much-needed look at the dangerous
epidemic of unnecessary or incorrect treatments in contemporary psychiatry. The last 30 …

Consensus of opinion is rare in psychiatry. Even in the field of clinical trials, where
experimentation is tightly controlled and regulatory bodies scrutinize the proof, controversies …

Pharmacology is focused on studying the effects of endogenous agents and xenobiotics on
tissue and organ function. Analysis of the concentration/response relationship is the …

Depressive disorders place a large burden on patients and on society. Although efficacious
treatment options for unipolar depressive disorders exist, substantial gaps in care remain. In …

" Dr. Paris has written an honest, balanced presentation of the ways in which psychiatric
drugs are evaluated and prescribed. He highlights the complexity of the task, the limits of …

Dysfunctional noradrenergic transmission is related to several neuropsychiatric conditions,
such as depression. Nowadays, the role of G protein-coupled inwardly rectifying potassium …

Einleitung: Ziel dieser systematischen Übersichtsarbeit ist es, die aktuelle wissenschaftliche
Evidenz zur Wirksamkeit einer professionell durchgeführten Massage auf Depressivität und …

So far, the mechanisms underlying the action of selective serotonin reuptake inhibitors, such
as fluoxetine, are not completely understood. Thus, to clarify if fluoxetine has any effect on …