Anhedonia is considered a core feature of major depressive disorder, and the dopamine
system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic …

Importance Computational psychiatry studies have investigated how reinforcement learning
may be different in individuals with mood and anxiety disorders compared with control …

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Extensive studies showed that monoaminergic neurotransmission that involves serotonin (5-
HT), norepinephrine (NE) and dopamine (DA) exerts major influence on brain circuits …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …

Serotonin regulates many physiological processes including sleep, appetite, and mood.
Thus, serotonergic system is an important target in the treatment of psychiatric disorders …

Atypical antipsychotic drugs were introduced in the early 1990s. Unlike typical
antipsychotics, which are effective only against positive symptoms of schizophrenia, atypical …

Cocaine exhibits prominent abuse liability, and chronic abuse can result in cocaine use
disorder with significant morbidity. Major advances have been made in delineating …

Depressed patients show cognitive deficits that may depend on an abnormal reaction to
positive and negative feedback. The precise neurochemical mechanisms responsible for …