Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …

Histone methylation plays a key function in modulating gene expression, and preserving
genome integrity and epigenetic inheritance. However, aberrations of histone methylation …

Schizophrenia (SZ) is a psychiatric disorder with complex genetic risk dictated by
interactions between hundreds of risk variants. Epigenetic factors, such as histone …

In recent years, it has become widely recognized that a comprehensive understanding of
chromatin biology is necessary to better appreciate its role in a wide range of diseases. The …

Epigenetic modifications, including DNA methylation, histone modifications, and non-coding
RNAs, have been implicated in a number of complex diseases. Schizophrenia and other …

It has been widely speculated that epigenetic changes may play a role in the etiology of
psychotic illnesses such as schizophrenia and bipolar disorder. Epigenetics is the study of …

Understanding the origins of normal and pathological behavior is one of the most exciting
opportunities in contemporary biomedical research. There is increasing evidence that, in …

Studies have demonstrated that several schizophrenia candidate genes are especially
susceptible to changes in transcriptional activity as a result of histone modifications and …

Objective Epigenetic changes are stable and long-lasting chromatin modifications that
regulate genomewide and local gene activity. The addition of two methyl groups to the 9th …

Schizophrenia is a severe psychiatric disease affecting about 1% of the world's population,
with significant effects on patients and society. Genetic studies have identified several …