Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

Mesocorticolimbic dopamine circuity undergoes a protracted maturation during adolescent
life. Stable adult levels of behavioral functioning in reward, motivational, and cognitive …

Backgroud Variations in the expression of the Netrin-1 guidance cue receptor DCC (deleted
in colorectal cancer) appear to confer resilience or susceptibility to psychopathologies …

A dramatic maturational process ongoing in adolescence is prefrontal cortex development,
including its dopamine innervation. Dopamine axons grow from the striatum to the prefrontal …

Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …

The Netrin-1/DCC guidance cue pathway plays a critical role in guiding growing axons
toward the prefrontal cortex during adolescence and in the maturational organization and …

Inhibitory control deficits are prevalent in multiple neuropsychiatric conditions. The
communication-as well as the connectivity-between corticolimbic regions of the brain are …

Netrins are guidance cues involved in neural connectivity. We have shown that the netrin-1
receptor DCC (deleted in colorectal cancer) is involved in the functional organization of the …

Genome-wide association studies (GWAS) of major depression and its relevant biological
phenotypes have been extensively conducted in large samples, and transcriptome-wide …

The exposure to stressful experiences during the prenatal period and through the first years
of life is known to affect the brain developmental trajectories, leading to an enhanced …