Current understanding of bipolar disorder: Toward integration of biological basis and treatment strategies
T Kato - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
Biological studies of bipolar disorder initially focused on the mechanism of action for
antidepressants and antipsychotic drugs, and the roles of monoamines (eg, serotonin …
antidepressants and antipsychotic drugs, and the roles of monoamines (eg, serotonin …
The glutamatergic aspects of schizophrenia molecular pathophysiology: role of the postsynaptic density, and implications for treatment
Schizophrenia is one of the most debilitating psychiatric diseases with a lifetime prevalence
of approximately 1%. Although the specific molecular underpinnings of schizophrenia are …
of approximately 1%. Although the specific molecular underpinnings of schizophrenia are …
[HTML][HTML] Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data
R Herbrechter, N Hube, R Buchholz… - Cellular and Molecular Life …, 2021 - Springer
Ionotropic glutamate receptors (iGluRs) play key roles for signaling in the central nervous
system. Alternative splicing and RNA editing are well-known mechanisms to increase iGluR …
system. Alternative splicing and RNA editing are well-known mechanisms to increase iGluR …
[HTML][HTML] A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia
Background Pre-mRNAs of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propanoic acid
(AMPA)/kainate glutamate receptors undergo post-transcriptional modification known as …
(AMPA)/kainate glutamate receptors undergo post-transcriptional modification known as …
Disruption of glutamate-glutamine-GABA cycle significantly impacts on suicidal behaviour: survey of the literature and own findings on glutamine synthetase.
HG Bernstein, A Tausch, R Wagner… - CNS & Neurological …, 2013 - ingentaconnect.com
The aetiology of suicide is complex and still not completely understood. The present
communication, which consists of two parts, aims to shed some light on the role of amino …
communication, which consists of two parts, aims to shed some light on the role of amino …
The good and the bad of glutamate receptor RNA editing
A Filippini, D Bonini, L La Via, A Barbon - Molecular Neurobiology, 2017 - Springer
Glutamate receptors play a key role in excitatory synaptic transmission and plasticity in the
central nervous system (CNS). Their channel properties are largely dictated by the subunit …
central nervous system (CNS). Their channel properties are largely dictated by the subunit …
The emerging role of dopamine–glutamate interaction and of the postsynaptic density in bipolar disorder pathophysiology: implications for treatment
A de Bartolomeis, EF Buonaguro… - Journal of …, 2014 - journals.sagepub.com
Aberrant synaptic plasticity, originating from abnormalities in dopamine and/or glutamate
transduction pathways, may contribute to the complex clinical manifestations of bipolar …
transduction pathways, may contribute to the complex clinical manifestations of bipolar …
Advances in the pharmacology of lGICs auxiliary subunits
Ligand-gated ion channels (LGICs) are cell surface integral proteins that mediate the fast
neurotransmission in the nervous system. LGICs require auxiliary subunits for their …
neurotransmission in the nervous system. LGICs require auxiliary subunits for their …
[HTML][HTML] mRNA editing of kainate receptor subunits: what do we know so far?
SG Gaidin, AM Kosenkov - Reviews in the Neurosciences, 2022 - degruyter.com
Kainate receptors (KARs) are considered one of the key modulators of synaptic activity in the
mammalian central nervous system. These receptors were discovered more than 30 years …
mammalian central nervous system. These receptors were discovered more than 30 years …
Deficits of Hippocampal RNA Editing and Social Interaction Resulting from Prenatal Stress are Mitigated by Clozapine
GC Bristow, E Dong, E Nwabuisi-Heath, S Gentile… - bioRxiv, 2021 - biorxiv.org
Background Neurodevelopmental deficits resulting from prenatal stress are associated with
neurological disorders that include deficits of social behavior, such as schizophrenia and …
neurological disorders that include deficits of social behavior, such as schizophrenia and …