Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …

Post-translational modification of substrate proteins by SUMO conjugation regulates a
diverse array of cellular processes. While predominantly a nuclear protein modification …

Post-translational protein modification by small ubiquitin-like modifier (SUMO) regulates a
myriad of homeostatic and stress responses. The SUMOylation pathway has been …

Stress is unavoidable and essential to cellular and organismal evolution and failure to adapt
or restore homeostasis can lead to severe diseases or even death. At the cellular level …

Background Mutations in the gene encoding the transcription factor forkhead box P2
(FOXP2) result in brain developmental abnormalities, including reduced gray matter in both …

Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995,
SUMOylation has been considered a crucial post-translational modification in diverse …

Background and Purpose—Small ubiquitin-like modifier (SUMO) conjugation is a post-
translational modification associated with many human diseases. Characterization of the …

Small ubiquitin-like modifier (SUMO1–3) conjugation (SUMOylation), a post-translational
modification, modulates almost all major cellular processes. Mounting evidence indicates …

Glucocorticoids (GCs) actions are mostly mediated by the GC receptor (GR), a member of
the nuclear receptor superfamily. Alterations of the GR activity have been associated to …

HDAC4 is a potent memory repressor with overexpression of wild type or a nuclear-
restricted mutant resulting in memory deficits. Interestingly, reduction of HDAC4 also impairs …