[HTML][HTML] Microbiome and immuno-metabolic dysregulation in patients with major depressive disorder with atypical clinical presentation

A Refisch, ZD Sen, TE Klassert, A Busch, B Besteher… - …, 2023 - Elsevier
Abstract Depression is highly prevalent (6% 1-year prevalence) and is the second leading
cause of disability worldwide. Available treatment options for depression are far from …

[HTML][HTML] The brain-adipocyte-gut network: Linking obesity and depression subtypes

CM Patist, NJC Stapelberg, EF Du Toit… - Cognitive, Affective, & …, 2018 - Springer
Major depressive disorder (MDD) and obesity are dominant and inter-related health
burdens. Obesity is a risk factor for MDD, and there is evidence MDD increases risk of …

The pathophysiology of major depressive disorder through the lens of systems biology: Network analysis of the psycho-immune-neuroendocrine physiome

NJC Stapelberg, TA Bui, V Mansour, S Johnson… - Journal of …, 2022 - Elsevier
Abstract Background/Aims The psycho-immune-neuroendocrine (PINE) network is a
predominantly physiological (metabolomic) model constructed from the literature, inter …

Health, pre-disease and critical transition to disease in the psycho-immune-neuroendocrine network: Are there distinct states in the progression from health to major …

NJC Stapelberg, DL Neumann, D Shum… - Physiology & …, 2019 - Elsevier
The psycho-immune-neuroendocrine (PINE) network is a regulatory network of interrelated
physiological pathways that have been implicated in major depressive disorder (MDD). A …

[HTML][HTML] Novel regulator of acylated ghrelin, CF801, reduces weight gain, rebound feeding after a fast, and adiposity in mice

MK Wellman, ZR Patterson, H MacKay… - Frontiers in …, 2015 - frontiersin.org
Ghrelin is a 28 amino acid hormonal peptide that is intimately related to the regulation of
food intake and body weight. Once secreted, ghrelin binds to the growth hormone …

The role of ghrelin and ghrelin O-acyltransferase in obesity: Targets for treatment

MK Wellman - 2016 - repository.library.carleton.ca
Ghrelin is the first identified circulating orexigenic hormone. Following translation of the
mRNA to its initial prepropeptide, a variety of posttranslational modifications are performed …