Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and
schizophrenia, affect a significant percentage of the world population. These disorders are …

Microglia, the resident immune cells in the brain, are essential for modulating neurogenesis,
influencing synaptic remodeling, and regulating neuroinflammation by surveying the brain …

The impact of infections and inflammation during pregnancy on the developing fetal brain
remains incompletely defined, with important clinical and research gaps. Although the …

Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …

Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Schizophrenia is a psychiatric disorder which has a lifetime prevalence of~ 1%. Multiple
candidate mechanisms have been proposed in the pathogenesis of schizophrenia. One …

An interaction between external stressors and intrinsic vulnerability is one of the longest
standing pathoaetiological explanations for schizophrenia. However, novel lines of evidence …

Elevated pro-inflammatory cytokines exist in both blood and brain of people with
schizophrenia but how this affects molecular indices of the blood–brain barrier (BBB) is …