Imaging the role of inflammation in mood and anxiety-related disorders
JC Felger - Current neuropharmacology, 2018 - ingentaconnect.com
Background: Studies investigating the impact of a variety of inflammatory stimuli on the brain
and behavior have reported evidence that inflammation and release of inflammatory …
and behavior have reported evidence that inflammation and release of inflammatory …
The origin of NMDA receptor hypofunction in schizophrenia
K Nakazawa, K Sapkota - Pharmacology & therapeutics, 2020 - Elsevier
Abstract N-methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …
[HTML][HTML] Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia
The kynurenine pathway (KP) of tryptophan (TRP) catabolism links immune system
activation with neurotransmitter signaling. The KP metabolite kynurenic acid (KYNA) is …
activation with neurotransmitter signaling. The KP metabolite kynurenic acid (KYNA) is …
Meta-analysis of cerebrospinal fluid cytokine and tryptophan catabolite alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder, and …
AK Wang, BJ Miller - Schizophrenia bulletin, 2018 - academic.oup.com
Introduction: Schizophrenia, bipolar disorder, and major depressive disorder (MDD) have all
been associated with immune system dysfunction, including aberrant cerebrospinal fluid …
been associated with immune system dysfunction, including aberrant cerebrospinal fluid …
[HTML][HTML] Inflammation effects on motivation and motor activity: role of dopamine
JC Felger, MT Treadway - Neuropsychopharmacology, 2017 - nature.com
Motivational and motor deficits are common in patients with depression and other psychiatric
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …
Kynurenine pathway in depression: A systematic review and meta-analysis
Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of
depression. However, the relationships between depression and each metabolite of the …
depression. However, the relationships between depression and each metabolite of the …
[HTML][HTML] Role of IL-6 in the regulation of neuronal development, survival and function
The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …
and destructive potentials. It can exert opposing actions triggering either neuron survival …
[HTML][HTML] Peripheral and central kynurenine pathway abnormalities in major depression
Considerable data relate major depressive disorder (MDD) with aberrant immune system
functioning. Pro-inflammatory cytokines facilitate metabolism of tryptophan along the …
functioning. Pro-inflammatory cytokines facilitate metabolism of tryptophan along the …
Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies
BackgroundConverging lines of evidence implicate an important role for the immune system
in schizophrenia. Microglia are the resident immune cells of the central nervous system and …
in schizophrenia. Microglia are the resident immune cells of the central nervous system and …
C-reactive protein is increased in schizophrenia but is not altered by antipsychotics: meta-analysis and implications
BS Fernandes, J Steiner, HG Bernstein, S Dodd… - Molecular …, 2016 - nature.com
The inflammatory hypothesis of schizophrenia (SZ) posits that inflammatory processes and
neural–immune interactions are involved in its pathogenesis, and may underpin some of its …
neural–immune interactions are involved in its pathogenesis, and may underpin some of its …