Wnt5a is the prototypical activator of the non-canonical Wnt pathways, and its
overexpression has been implicated in the progression of several tumor types by promoting …

Progranulin (PGRN) is a growth factor with a unique beads‐on‐a‐string structure that is
involved in multiple pathophysiological processes, including anti‐inflammation, tissue …

Hydrogels with long-term storage stability, controllable sustained-release properties, and
biocompatibility have been garnering attention as carriers for drug/growth factor delivery in …

Loss-of-function (LOF) mutations in GRN gene, which encodes progranulin (PGRN), cause
frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). FTLD-TDP is one of …

Objective To determine whether exosomal microRNAs (miRNAs) in cerebrospinal fluid
(CSF) of patients with frontotemporal dementia (FTD) can serve as diagnostic biomarkers …

Background: Chronic glial dysfunction may contribute to the pathogenesis of frontotemporal
dementia (FTD). Cerebrospinal fluid (CSF) levels of glia-derived proteins YKL-40 and …

Type 2 diabetes mellitus (T2DM) significantly increases bone fragility and fracture risk.
Progranulin (PGRN) promotes bone fracture healing in both physiological and type 1 …

Immune dysregulation has been identified as a critical cause of the most common types of
cardiovascular diseases (CVDs). Notably, the innate and adaptive immune responses under …

Aseptic loosening is a major complication of prosthetic joint surgery, characterized by
chronic inflammation, pain and osteolysis surrounding the bone-implant interface …

Background Mesothelioma is an aggressive disease with limited therapeutic options. The
growth factor progranulin plays a critical role in several cancer models, where it regulates …