Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia

CA Moreau, SGW Urchs, K Kuldeep, P Orban… - Nature …, 2020 - nature.com
Abstract 16p11. 2 and 22q11. 2 Copy Number Variants (CNVs) confer high risk for Autism
Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder …

Real-time fMRI neurofeedback reduces auditory hallucinations and modulates resting state connectivity of involved brain regions: Part 2: Default mode network …

CCC Bauer, K Okano, SS Ghosh, YJ Lee, H Melero… - Psychiatry …, 2020 - Elsevier
Auditory hallucinations (AHs) are one of the most distressing symptoms of schizophrenia
(SZ) and are often resistant to medication. Imaging studies of individuals with SZ show …

Changes in default-mode network associated with childhood trauma in schizophrenia

MR Dauvermann, D Mothersill, KI Rokita… - Schizophrenia …, 2021 - academic.oup.com
Background There is considerable evidence of dysconnectivity within the default-mode
network (DMN) in schizophrenia, as measured during resting-state functional MRI (rs-fMRI) …

Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions

CA Moreau, K Kumar, A Harvey, G Huguet, SGW Urchs… - Brain, 2023 - academic.oup.com
Pleiotropy occurs when a genetic variant influences more than one trait. This is a key
property of the genomic architecture of psychiatric disorders and has been observed for rare …

Neurofeedback of core language network nodes modulates connectivity with the default-mode network: a double-blind fMRI neurofeedback study on auditory verbal …

J Zweerings, B Hummel, M Keller, M Zvyagintsev… - Neuroimage, 2019 - Elsevier
Background The experience of auditory verbal hallucinations in schizophrenia is associated
with changes in brain network function. In particular, studies indicate altered functional …

Genetic heterogeneity shapes brain connectivity in psychiatry

CA Moreau, A Harvey, K Kumar, G Huguet… - Biological …, 2023 - Elsevier
Background Polygenicity and genetic heterogeneity pose great challenges for studying
psychiatric conditions. Genetically informed approaches have been implemented in …

Multisite generalizability of schizophrenia diagnosis classification based on functional brain connectivity

P Orban, C Dansereau, L Desbois… - Schizophrenia …, 2018 - Elsevier
Our objective was to assess the generalizability, across sites and cognitive contexts, of
schizophrenia classification based on functional brain connectivity. We tested different …

Multivariate classification of schizophrenia and its familial risk based on load-dependent attentional control brain functional connectivity

LA Antonucci, N Penzel, G Pergola… - …, 2020 - nature.com
Patients with schizophrenia (SCZ), as well as their unaffected siblings (SIB), show functional
connectivity (FC) alterations during performance of tasks involving attention. As compared …

Task modulations and clinical manifestations in the brain functional connectome in 1615 fMRI datasets

T Kaufmann, D Alnæs, CL Brandt, NT Doan, K Kauppi… - Neuroimage, 2017 - Elsevier
Objective An abundance of experimental studies have motivated a range of models
concerning the cognitive underpinnings of severe mental disorders, yet the conception that …

[HTML][HTML] Cannabidiol displays proteomic similarities to antipsychotics in cuprizone-exposed human oligodendrocytic cell line MO3. 13

ACB Falvella, BJ Smith, LC Silva-Costa… - Frontiers in molecular …, 2021 - frontiersin.org
Cannabidiol, a compound of Cannabis sativa, has been proposed as an alternative
treatment of schizophrenia. Preclinical and clinical data have suggested that cannabidiol …