The neurobiology of activational aspects of motivation: exertion of effort, effort-based decision making, and the role of dopamine
JD Salamone, M Correa - Annual Review of Psychology, 2024 - annualreviews.org
Motivational processes are complex and multifaceted, with both directional and activational
aspects. Behavioral activation and exertion of effort are functions that enable organisms to …
aspects. Behavioral activation and exertion of effort are functions that enable organisms to …
Deciphering decision making: variation in animal models of effort-and uncertainty-based choice reveals distinct neural circuitries underlying core cognitive processes
CA Winstanley, SB Floresco - Journal of Neuroscience, 2016 - Soc Neuroscience
Maladaptive decision-making is increasingly recognized to play a significant role in
numerous psychiatric disorders, such that therapeutics capable of ameliorating core …
numerous psychiatric disorders, such that therapeutics capable of ameliorating core …
The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse
SM Mooney-Leber, TJ Gould - Learning & memory, 2018 - learnmem.cshlp.org
During adolescence, the brain continues to undergo vital developmental processes. In turn,
complex behavioral and cognitive skills emerge. Unfortunately, neurobiological …
complex behavioral and cognitive skills emerge. Unfortunately, neurobiological …
Cannabinoid-based therapies and brain development: potential harmful effect of early modulation of the endocannabinoid system
P Schonhofen, IJ Bristot, JA Crippa, JEC Hallak… - CNS drugs, 2018 - Springer
The endocannabinoid retrograde signaling pathway is widely expressed in the central
nervous system, where it plays major roles in regulating synaptic plasticity (excitatory and …
nervous system, where it plays major roles in regulating synaptic plasticity (excitatory and …
[HTML][HTML] A systematic review of human neuroimaging evidence of memory-related functional alterations associated with cannabis use complemented with preclinical …
G Blest-Hopley, V Giampietro, S Bhattacharyya - Brain Sciences, 2020 - mdpi.com
Cannabis has been associated with deficits in memory performance. However, the neural
correlates that may underpin impairments remain unclear. We carried out a systematic …
correlates that may underpin impairments remain unclear. We carried out a systematic …
Seeing through the smoke: human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks
MM Silveira, JC Arnold, SR Laviolette, CJ Hillard… - Neuroscience & …, 2017 - Elsevier
Public opinion surrounding the recreational use and therapeutic potential of cannabis is
shifting. This review describes new work examining the behavioural and neural effects of …
shifting. This review describes new work examining the behavioural and neural effects of …
Functional effects of synthetic cannabinoids versus Δ9‐THC in mice on body temperature, nociceptive threshold, anxiety, cognition, locomotor/exploratory parameters …
S Schreiber, M Bader, T Lenchinski… - Addiction …, 2019 - Wiley Online Library
Synthetic cannabinoids are psychoactive substances designed to mimic the euphorigenic
effects of the natural cannabis. Novel unregulated compounds appear once older …
effects of the natural cannabis. Novel unregulated compounds appear once older …
[HTML][HTML] Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women
Background The use of cannabis has been clinically associated with decreased motivation
to engage in normally rewarding activities. However, evidence from previous controlled …
to engage in normally rewarding activities. However, evidence from previous controlled …
Residual effects of cannabis use on effort-based decision-making
MB Taylor, FM Filbey - Journal of the International …, 2021 - cambridge.org
Objective: Acute Δ9-tetrahydrocannabinol (THC) administration in humans (Lawn etal.,
2016) and rats (Silveira, Adams, Morena, Hill, & Winstanley, 2016) has been associated with …
2016) and rats (Silveira, Adams, Morena, Hill, & Winstanley, 2016) has been associated with …
[HTML][HTML] Examination of the effects of cannabinoid ligands on decision making in a rat gambling task
JMN Ferland, MR Carr, AM Lee, ME Hoogeland… - Pharmacology …, 2018 - Elsevier
Although exposure to delta-9-tetrahydrocannabinol (THC) is perceived to be relatively
harmless, mounting evidence has begun to show that it is associated with a variety of …
harmless, mounting evidence has begun to show that it is associated with a variety of …