Association of ketamine with psychiatric symptoms and implications for its therapeutic use and for understanding schizophrenia: a systematic review and meta …
Importance Ketamine hydrochloride is increasingly used to treat depression and other
psychiatric disorders but can induce schizophrenia-like or psychotomimetic symptoms …
psychiatric disorders but can induce schizophrenia-like or psychotomimetic symptoms …
[HTML][HTML] A selective review of the excitatory-inhibitory imbalance in schizophrenia: underlying biology, genetics, microcircuits, and symptoms
Y Liu, P Ouyang, Y Zheng, L Mi, J Zhao… - Frontiers in cell and …, 2021 - frontiersin.org
Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …
[HTML][HTML] Ketamine modulates fronto-striatal circuitry in depressed and healthy individuals
Ketamine improves motivation-related symptoms in depression but simultaneously elicits
similar symptoms in healthy individuals, suggesting that it might have different effects in …
similar symptoms in healthy individuals, suggesting that it might have different effects in …
[HTML][HTML] The Altered States Database: Psychometric data from a systematic literature review
J Prugger, E Derdiyok, J Dinkelacker, C Costines… - Scientific data, 2022 - nature.com
In this paper, we present the development of the Altered States Database (ASDB), an open-
science project based on a systematic literature review. The ASDB contains psychometric …
science project based on a systematic literature review. The ASDB contains psychometric …
An active inference perspective on the negative symptoms of schizophrenia
J Jeganathan, M Breakspear - The Lancet Psychiatry, 2021 - thelancet.com
Predictive coding has played a transformative role in the study of psychosis, casting
delusions and hallucinations as statistical inference in a system with abnormal precision …
delusions and hallucinations as statistical inference in a system with abnormal precision …
[HTML][HTML] Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway
X Ouyang, Z Wang, M Luo, M Wang, X Liu, J Chen… - Scientific Reports, 2021 - nature.com
To investigate the effects of ketamine on glucose uptake and glucose transporter (GLUT)
expression in depressive-like mice. After HA1800 cells were treated with ketamine, 2-[N-(7 …
expression in depressive-like mice. After HA1800 cells were treated with ketamine, 2-[N-(7 …
[HTML][HTML] Selective prefrontal disinhibition in a roving auditory oddball paradigm under N-methyl-D-aspartate receptor blockade
RE Rosch, R Auksztulewicz, PD Leung… - Biological Psychiatry …, 2019 - Elsevier
Background Disturbances in N-methyl-D-aspartate receptors (NMDARs)—as implicated in
patients with schizophrenia—can cause regionally specific electrophysiological effects. Both …
patients with schizophrenia—can cause regionally specific electrophysiological effects. Both …
[HTML][HTML] Negative symptoms of schizophrenia and dopaminergic transmission: translational models and perspectives opened by iPSC techniques
Negative symptoms (NS) represent a heterogeneous dimension of schizophrenia (SCZ),
associated with a poor functional outcome. A dysregulated dopamine (DA) system, including …
associated with a poor functional outcome. A dysregulated dopamine (DA) system, including …
[HTML][HTML] Ketamine alters functional gamma and theta resting-state connectivity in healthy humans: implications for schizophrenia treatment targeting the glutamate …
Disturbed functional connectivity is assumed to cause neurocognitive deficits in patients
suffering from schizophrenia. A Glutamate N-methyl-D-aspartate receptor (NMDAR) …
suffering from schizophrenia. A Glutamate N-methyl-D-aspartate receptor (NMDAR) …
[HTML][HTML] Drugs based on NMDAR hypofunction hypothesis in schizophrenia
Q Wu, J Huang, R Wu - Frontiers in Neuroscience, 2021 - frontiersin.org
Treatments for negative symptoms and cognitive dysfunction in schizophrenia remain issues
that psychiatrists around the world are trying to solve. Their mechanisms may be associated …
that psychiatrists around the world are trying to solve. Their mechanisms may be associated …