Oxidative stress in depression: the link with the stress response, neuroinflammation, serotonin, neurogenesis and synaptic plasticity

AS Correia, A Cardoso, N Vale - Antioxidants, 2023 - mdpi.com
Depression is a prevalent, complex, and highly debilitating disease. The full comprehension
of this disease is still a global challenge. Indeed, relapse, recurrency, and therapeutic …

Depression, dementia and immune dysregulation

S Hayley, AM Hakim, PR Albert - Brain, 2021 - academic.oup.com
Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …

A specific inflammatory profile underlying suicide risk? Systematic review of the main literature findings

G Serafini, VM Parisi, A Aguglia, A Amerio… - International journal of …, 2020 - mdpi.com
Consistent evidence indicates the association between inflammatory markers and suicidal
behavior. The burden related to immunological differences have been widely documented in …

[HTML][HTML] Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?

GA Porter, JC O'Connor - World journal of psychiatry, 2022 - ncbi.nlm.nih.gov
Major depressive disorder is a debilitating disorder affecting millions of people each year.
Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk …

[HTML][HTML] Nrf2: An all-rounder in depression

C Zuo, H Cao, Y Song, Z Gu, Y Huang, Y Yang, J Miao… - Redox biology, 2022 - Elsevier
The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …

The emerging tale of microglia in psychiatric disorders

R Rahimian, M Wakid, LA O'Leary… - … & Biobehavioral Reviews, 2021 - Elsevier
As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …

[HTML][HTML] Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression

MA Tayab, MN Islam, KAA Chowdhury… - Biomedicine & …, 2022 - Elsevier
Depression is the most prevalent and debilitating mental disorder that affects a substantial
number of people globally, hindering all aspects of their lives and leading to a high number …

The role of damage associated molecular pattern molecules (DAMPs) and permeability of the blood-brain barrier in depression and neuroinflammation

MF Serna-Rodríguez, S Bernal-Vega… - Journal of …, 2022 - Elsevier
Depression is a heterogeneous mental disorder characterized by feelings of sadness and
loss of interest that render the subject unable to handle basic daily activities such as …

Role of interleukin 8 in depression and other psychiatric disorders

SJ Tsai - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Low grade neuroinflammation has been suggested as one of the underlying mechanisms of
many psychiatric diseases as well as cognitive disorders. Interleukin 8 (IL-8), a …

BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α

JJ Lu, PF Wu, JG He, YK Li, LH Long, XP Yao… - Molecular …, 2023 - nature.com
Recent studies based on animal models of various neurological disorders have indicated
that mitophagy, a selective autophagy that eliminates damaged and superfluous …