Structural and functional brain alterations are common in patients with major depressive
disorder (MDD). In this review, we assessed the recent literature (1995–2018) on the …

Medial temporal lobe structures have long been implicated in the pathogenesis of major
depressive disorder. Although findings of smaller hippocampal and amygdalar volumes are …

The nucleus accumbens (NAc) is considered a hub of reward processing and a growing
body of evidence has suggested its crucial role in the pathophysiology of major depressive …

Abstract Background The nucleus accumbens (NAc) is an important region in reward circuit
that has been linked with anhedonia, which is a characteristic symptom of major depressive …

Recent neuroimaging studies have characterized the pathophysiology of late-life depression
(LLD) as a dysfunction of the brain networks involved in the regulation of emotion …

Major depressive disorder (MDD) is a highly heterogeneous mental disorder, and its
complex etiology and unclear mechanism are great obstacles to the diagnosis and treatment …

Major depressive disorder (MDD) is a common psychiatric illness with a wide range of
symptoms such as mood decline, loss of interest, and feelings of guilt and worthlessness …

Background As a neuroprogressive illness, depression is accompanied by brain structural
abnormality that extends to many brain regions. However, the progressive structural …

The role of the amygdala in the experience of emotional states and stress is well
established. Connections from the amygdala to the hypothalamus activate the hypothalamic …

Depression is assessed in various ways in research, with large population studies often
relying on minimal phenotyping. Genetic results suggest clinical diagnoses and self-report …