[HTML][HTML] Epigenetic targeting of histone deacetylases in diagnostics and treatment of depression
HS Park, J Kim, SH Ahn, HY Ryu - International journal of molecular …, 2021 - mdpi.com
Depression is a highly prevalent, disabling, and often chronic illness that places substantial
burdens on patients, families, healthcare systems, and the economy. A substantial minority …
burdens on patients, families, healthcare systems, and the economy. A substantial minority …
[HTML][HTML] Meta-analysis of cortical thickness abnormalities in medication-free patients with major depressive disorder
Alterations in cortical thickness have been identified in major depressive disorder (MDD),
but findings have been variable and inconsistent. To date, no reliable tools have been …
but findings have been variable and inconsistent. To date, no reliable tools have been …
[HTML][HTML] The relationship between stress, inflammation, and depression
IB Kim, JH Lee, SC Park - Biomedicines, 2022 - mdpi.com
A narrative review about the relationship between stress, inflammation, and depression is
made as follows: Chronic stress leads to various stress-related diseases such as …
made as follows: Chronic stress leads to various stress-related diseases such as …
[HTML][HTML] Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder
Inflammatory processes are implicated in the aetiology of Major Depressive Disorder (MDD);
however, the relationship between peripheral inflammation, brain structure and depression …
however, the relationship between peripheral inflammation, brain structure and depression …
[HTML][HTML] Pathological fear, anxiety and negative affect exhibit distinct neurostructural signatures: evidence from psychiatric neuroimaging meta-analysis
Internalizing disorders encompass anxiety, fear and depressive disorders, which exhibit
overlap at both conceptual and symptom levels. Given that a neurobiological evaluation is …
overlap at both conceptual and symptom levels. Given that a neurobiological evaluation is …
Increased peripheral inflammation in schizophrenia is associated with worse cognitive performance and related cortical thickness reductions
HF North, J Bruggemann, V Cropley… - European archives of …, 2021 - Springer
While the biological substrates of brain and behavioural changes in persons with
schizophrenia remain unclear, increasing evidence implicates that inflammation is involved …
schizophrenia remain unclear, increasing evidence implicates that inflammation is involved …
Antidepressive effect of arctiin by attenuating neuroinflammation via HMGB1/TLR4-and TNF-α/TNFR1-mediated NF-κB activation
X Xu, XY Zeng, YX Cui, YB Li, JH Cheng… - ACS chemical …, 2020 - ACS Publications
Inflammation is a potential factor in the pathophysiology of depression. A traditional Chinese
herbal medicine, arctiin, and its aglycone, arctigenin, are the major bioactive components in …
herbal medicine, arctiin, and its aglycone, arctigenin, are the major bioactive components in …
No evidence for clinical efficacy of adjunctive celecoxib with vortioxetine in the treatment of depression: A 6-week double-blind placebo controlled randomized trial
BT Baune, E Sampson, J Louise, H Hori… - European …, 2021 - Elsevier
Given the role of low-grade inflammation in the pathophysiology of major depressive
disorder (MDD), anti-inflammatory strategies may improve treatment outcomes in some …
disorder (MDD), anti-inflammatory strategies may improve treatment outcomes in some …
C-Reactive protein and the kynurenic acid to quinolinic acid ratio are independently associated with white matter integrity in major depressive disorder
Kynurenic acid (KynA) and quinolinic acid (QA) are neuroactive kynurenine pathway (KP)
metabolites that have neuroprotective and neurotoxic properties, respectively. At least partly …
metabolites that have neuroprotective and neurotoxic properties, respectively. At least partly …
Childhood maltreatment influences adult brain structure through its effects on immune, metabolic, and psychosocial factors
SC Orellana, RAI Bethlehem… - Proceedings of the …, 2024 - National Acad Sciences
Childhood maltreatment (CM) leads to a lifelong susceptibility to mental ill-health which
might be reflected by its effects on adult brain structure, perhaps indirectly mediated by its …
might be reflected by its effects on adult brain structure, perhaps indirectly mediated by its …
