Can epigenetics shine a light on the biological pathways underlying major mental disorders?

L Alameda, G Trotta, H Quigley, V Rodriguez… - Psychological …, 2022 - cambridge.org
A significant proportion of the global burden of disease can be attributed to mental illness.
Despite important advances in identifying risk factors for mental health conditions, the …

[HTML][HTML] Eating disorders, heredity and environmental activation: getting epigenetic concepts into practice

H Steiger, L Booij - Journal of clinical medicine, 2020 - mdpi.com
Epigenetic mechanisms are believed to link environmental exposures to alterations in gene
expression, and in so doing, to provide a physical substrate for the activation of hereditary …

[HTML][HTML] Gene variants in eating disorders. Focus on anorexia nervosa, bulimia nervosa, and binge-eating disorder

K Donato, MR Ceccarini, K Dhuli, G Bonetti… - Journal of Preventive …, 2022 - ncbi.nlm.nih.gov
Eating disorders such as anorexia nervosa, bulimia nervosa and binge-eating disorder,
have a deep social impact, concluding with death in cases of severe disease. Eating …

[HTML][HTML] SLC6A4 DNA Methylation Levels and Serum Kynurenine/Tryptophan Ratio in Eating Disorders: A Possible Link with Psychopathological Traits?

M Franzago, E Orecchini, A Porreca, G Mondanelli… - Nutrients, 2023 - mdpi.com
Background: The incidence of eating disorders (EDs), serious mental and physical
conditions characterized by a disturbance in eating or eating-related behaviors, has …

[HTML][HTML] Inclusion of the severe and enduring anorexia nervosa phenotype in genetics research: a scoping review

S Ramsay, K Allison, HS Temples, L Boccuto… - Journal of Eating …, 2024 - Springer
Background Anorexia nervosa has one of the highest mortality rates of all mental illnesses.
For those who survive, less than 70% fully recover, with many going on to develop a more …

[HTML][HTML] Applying epigenetic science to the understanding of eating disorders: A promising paradigm for research and practice

L Booij, H Steiger - Current Opinion in Psychiatry, 2020 - journals.lww.com
Epigenetic studies in the eating disorders corroborate the idea that eating disorder cause is
multifactorial, and identify markers that could help inform our understanding of illness …

[HTML][HTML] Brain and gut microbiota disorders in the psychopathology of anorexia nervosa

M Garcia-Gil, MR Ceccarini, F Stoppini… - Translational …, 2022 - degruyter.com
Studies of pathophysiological mechanisms involved in eating disorders (EDs) have
intensified over the past several years, revealing their unprecedented and unanticipated …

Acute tryptophan depletion balances altered resting-state functional connectivity of the salience network in female patients recovered from anorexia nervosa

I Boehm, J Hennig, F Ritschel, D Geisler, JA King… - Journal of Psychiatry and …, 2022 - jpn.ca
Background: It has been suggested that individuals predisposed to or recovered from
anorexia nervosa experience a hyperserotonergic state associated with anxiety that might …

[PDF][PDF] Hypermethylation of the serotonin transporter gene and paternal parenting styles in untreated anorexia nervosa patients: A pilot study

Q He, C Lian, S Peng, H Chen, Q Kang, J Chen - Heliyon, 2023 - cell.com
Purpose It has been reported that serotonergic systems and parenting styles are involved in
the pathogenesis of anorexia nervosa (AN). The present study made attempts to examine …

Epigenotoxicity: a danger to the future life

F Kefayati, A Karimi Babaahmadi… - … Science and Health …, 2023 - Taylor & Francis
Environmental toxicants can regulate gene expression in the absence of DNA mutations via
epigenetic mechanisms such as DNA methylation, histone modifications, and non-coding …