The orphan receptor GPR88 controls impulsivity and is a risk factor for attention-deficit/hyperactivity disorder
S Ben Hamida, SM Sengupta, E Clarke… - Molecular …, 2022 - nature.com
The neural orphan G protein coupled receptor GPR88 is predominant in the striatum and
cortex of both rodents and humans, and considered a potential target for brain disorders …
cortex of both rodents and humans, and considered a potential target for brain disorders …
Design, Synthesis, and Structure–Activity Relationship Studies of Novel GPR88 Agonists (4-Substituted-phenyl) acetamides Based on the Reversed Amide Scaffold
The development of synthetic agonists for the orphan receptor GPR88 has recently attracted
significant interest, given the promise of GPR88 as a novel drug target for psychiatric and …
significant interest, given the promise of GPR88 as a novel drug target for psychiatric and …
Orphans to the rescue: orphan G-protein coupled receptors as new antidepressant targets
PR Albert - Journal of Psychiatry and Neuroscience, 2020 - jpn.ca
Are orphan G-protein coupled receptors (oGPRs) the next frontier in psychiatric drug
targets? Several recent papers suggest that this may finally be the case. G-protein coupled …
targets? Several recent papers suggest that this may finally be the case. G-protein coupled …
Benchmarking Modeling Methods for G Protein Coupled Receptor Ligand Discovery and Application to Orphan Receptors BB3, GPR88 and GPR52
PN Potts - 2022 - search.proquest.com
The diversity of the known and presumed physiological roles of the members of the GPCR
superfamily motivate studies to expand both pharmacological and general knowledge …
superfamily motivate studies to expand both pharmacological and general knowledge …
The Orphan Receptor GPR88 Controls Impulsivity and Is a Risk Factor for Attention-Deficit/Hyperactivity Disorder
B Kieffer, SB Hamida, S Sengupta, E Clarke… - 2022 - researchsquare.com
The neural orphan G protein coupled receptor GPR88 is predominant in the striatum and
cortex of both rodents and humans, and considered a potential target for brain disorders …
cortex of both rodents and humans, and considered a potential target for brain disorders …
Molecular modeling and simulation studies to prioritize sequence variants identified by whole-exome sequencing in a South African family with Parkinson's disease
M Hassan - 2021 - etd.uwc.ac.za
Parkinson's disease (PD) is a neurodegenerative disorder that occurs due to a loss of
dopaminergic neurons in the substantia nigra. It is one of the most common …
dopaminergic neurons in the substantia nigra. It is one of the most common …