Here an overview is provided on therapeutic/neuroprotective effects of Lithium (Li+) in
neurodegenerative and psychiatric disorders focusing on the conspicuous action of Li+ …

Over the last six decades, lithium has been considered the gold standard treatment for the
long-term management of bipolar disorder due to its efficacy in preventing both manic and …

Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and
disabling mental health disorder that affects about 1% of the population worldwide …

Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of
lithium ions on mood regulation in bipolar disorder and other mental illnesses, including …

Trace elements or trace metals are essential components of enzymes, proteins, hormones
and play a key role in biochemical processes, cell growth and differentiation, as well as in …

G protein-coupled receptors (GPCRs) are intricately involved in the conversion of
extracellular feedback to intracellular responses. These specialized receptors possess a …

Bipolar disorder (BD) is a severe and chronic psychiatric disorder that affects approximately
1–4% of the world population and is characterized by recurrent episodes of mania or …

Several neurodegenerative diseases and neuropsychiatric disorders display aberrant
posttranslational modifications (PTMs) of one, or many, proteins. Lithium treatment has been …

The USP19 deubiquitinase is found in a locus associated with Parkinson's Disease (PD),
interacts with chaperonins, and promotes secretion of α-synuclein (α-syn) through the …

Essential tremor (ET) is one of the most common movement disorders, affecting nearly 5% of
individuals over 65 years old. Despite this, few genetic risk loci for ET have been identified …