Astrocytes in Post-Stroke Depression: Roles in Inflammation, Neurotransmission, and Neurotrophin Signaling

D Jing, X Hou, X Guo, X Zhao, K Zhang… - Cellular and Molecular …, 2023 - Springer
Post-stroke depression (PSD) is a frequent and disabling complication of stroke that affects
up to one-third of stroke survivors. The pathophysiology of PSD involves multiple …

[HTML][HTML] Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke

YQ Feng, ZZ Xu, YT Wang, Y Xiong, W Xie… - Frontiers in Cellular …, 2022 - frontiersin.org
Stroke is the world's second major cause of adult death and disability, resulting in the
destruction of brain tissue and long-term neurological impairment; induction of neuronal …

The role of microglia heterogeneity in synaptic plasticity and brain disorders: Will sequencing shed light on the discovery of new therapeutic targets?

Y You, Z Chen, WW Hu - Pharmacology & Therapeutics, 2024 - Elsevier
Microglia play a crucial role in interacting with neuronal synapses and modulating synaptic
plasticity. This function is particularly significant during postnatal development, as microglia …

CCR5 and Inflammatory Storm

Y Lin, S Liu, Y Sun, C Chen, S Yang, G Pei, M Lin… - Ageing Research …, 2024 - Elsevier
Chemokines and their corresponding receptors play crucial roles in orchestrating
inflammatory and immune responses, particularly in the context of pathological conditions …

CCR5‐Δ32 polymorphism—a possible protective factor from gait impairment amongst post‐stroke patients

J Molad, H Hallevi, E Seyman… - European Journal of …, 2023 - Wiley Online Library
Background and purpose Stroke and small vessel disease cause gait disturbances and falls.
The naturally occurring loss‐of‐function mutation in the C‐C chemokine receptor 5 gene …

[PDF][PDF] The CRISPR-Cas9 induced CCR5 Δ32 mutation as a potent gene therapy methodology for resistance to HIV-1 variant: a review.

M Saifullah, O Laghzaoui… - European Review for …, 2024 - europeanreview.org
Human Immunodeficiency Virus (HIV) has continuously been the greatest epidemic for
humanity over a period spanning almost five decades. With no specific cure or treatment …

[HTML][HTML] Influence of functional gene polymorphisms on human behaviour: the case of CCR5

PR Albert - Journal of Psychiatry and Neuroscience, 2021 - jpn.ca
The idea that genetic changes can impact behaviour and lead to novel therapeutic
approaches for mental illness has been an attractive, yet elusive hypothesis. A couple of …