Objective To integrate all evidence derived from randomized controlled trials (RCTs) of both
pharmacological and nonpharmacological augmentation interventions for clozapine …

Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …

This systematic review aimed to review neuroimaging studies comparing clozapine-resistant
schizophrenia patients with clozapine-responding patients, and with first-line antipsychotic …

During adolescence, the brain undergoes extensive changes in white matter structure that
support cognition. Data-driven approaches applied to cortical surface properties have led …

Previous studies reported decreased glutamate levels in the anterior cingulate cortex (ACC)
in non-treatment-resistant schizophrenia and first-episode psychosis. However, ACC …

Background Electroconvulsive therapy (ECT) is one of the most effective treatments for
depression and schizophrenia, particularly in urgent or treatment-resistant cases. After ECT …

The increasing availability of large-scale neuroimaging initiatives opens exciting
opportunities for discovery science of human brain structure and function. Data-driven …

Abstract Background and Hypothesis Given the heterogeneity and possible disease
progression in schizophrenia, identifying the neurobiological subtypes and progression …

Orthonormal projective non-negative matrix factorization (opNMF) has been widely used in
neuroimaging and clinical neuroscience applications to derive representations of the brain …

The emergence of the psychosis spectrum (PS; subclinical psychosis-related symptoms)
during late childhood and adolescence (ie, youth) coincides with a period of dynamic …