Background Only 35% of patients with major depressive disorder remit after first-line
treatment on medications with antidepressant properties. Furthermore, sex differences in …

There has been a recent increase in the number of studies examining experiences of
adversity in early life and subsequent brain development. This work reflects fundamental …

Background Adolescence is a period of maturation of self-control, consideration of future
consequences, planning, and socialization skills, and eventually reductions in risk taking …

Hannah Savage: Clarifying the neural substrates of threat and safety reversal learning in
humans Kristina Sabaroedin: Effective connectivity of frontostriatal systems in first-episode …

A greater appreciation of the integrative relationship between the immune system and
central nervous system is emerging in light of evidence suggesting that bidirectional …

The overarching theme of this dissertation was to separate the causal influences of familial
risk toward substance misuse (eg, genetic liability) from the potential effects of alcohol and …

A wide range of mental illnesses show high rates of addiction comorbidities regardless of
their genetic, neurodevelopmental, and/or adverse-environmental etiologies. Understanding …

Can we one day prevent mental disorders? Mukherjee et al.(2019) use a genetic mouse
model of schizophrenia-risk with established abnormalities in adult hippocampal-prefrontal …

The coronavirus disease 2019 (COVID-19) pandemic highlights longstanding health
disparities in the United States. African American individuals contract the disease at much …

In humans, adverse social exposures (ASEs) such as stress or trauma can exert both acute
and long-lasting biological and psychological effects. This is especially true during critical …