Gut feelings about depression
The perspective that eating and obesity are linked to depressive disorders has gained
considerable purchase, in part, because of the attention devoted to obesity in general, the …
considerable purchase, in part, because of the attention devoted to obesity in general, the …
The leptin hypothesis of depression: a potential link between mood disorders and obesity?
XY Lu - Current opinion in pharmacology, 2007 - Elsevier
The adipose-derived hormone leptin is well known for its function in the control of energy
homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of …
homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of …
Leptin: a potential novel antidepressant
Leptin, a hormone secreted from adipose tissue, was originally discovered to regulate body
weight. The localization of the leptin receptor in limbic structures suggests a potential role for …
weight. The localization of the leptin receptor in limbic structures suggests a potential role for …
[CITATION][C] The counterbalance between leptin and cortisol may be associated with comorbid depression and anxiety
SC LIAO, MB LEE, YUEJOE LEE… - Psychiatry and Clinical …, 2006 - Wiley Online Library
Details of the psychopathologic relationship that exists between major depression and leptin
are uncertain. However, the comorbidity which is known to occur between major depression …
are uncertain. However, the comorbidity which is known to occur between major depression …
The association between leptin and depressive symptoms is modulated by abdominal adiposity
Background Evidence for a role of leptin in depression is limited and conflicting.
Inconclusive findings may be explained by the complex effect of obesity on leptin signaling …
Inconclusive findings may be explained by the complex effect of obesity on leptin signaling …
[HTML][HTML] Leptin's Inverse Association with Brain Morphology and Depressive Symptoms–A Discovery and Confirmatory Study Across Two Independent Samples
Abstract Background Major Depressive Disorder (MDD) has a complex, bi-directional
relationship with metabolic dysfunction, yet the neural correlates of this association are not …
relationship with metabolic dysfunction, yet the neural correlates of this association are not …
[HTML][HTML] The role of leptin in indirectly mediating “somatic anxiety” symptoms in major depressive disorder
Y Zhu, Y Wei, J Duan, J Li, R Zhang, J Sun… - Frontiers in …, 2022 - frontiersin.org
Background Leptin is a multifunctional hormone secreted from adipose tissue, which plays a
core role in regulating energy intake and expenditure. Evidence has demonstrated that …
core role in regulating energy intake and expenditure. Evidence has demonstrated that …
Impaired CNS leptin action is implicated in depression associated with obesity
N Yamada, G Katsuura, Y Ochi, K Ebihara… - …, 2011 - academic.oup.com
Recent epidemiological studies indicate that obesity increases the incidence of depression.
We examined the implication of leptin for obesity-associated depression. Leptin induced …
We examined the implication of leptin for obesity-associated depression. Leptin induced …
High serum leptin levels in depressive disorders with atypical features
Leptin is thought to be related to vegetative symptoms of depression such as alterations in
food intake and weight. Fifty‐seven drug‐free patients and 26 healthy controls were enrolled …
food intake and weight. Fifty‐seven drug‐free patients and 26 healthy controls were enrolled …
[HTML][HTML] Leptin in depression: a potential therapeutic target
T Ge, J Fan, W Yang, R Cui, B Li - Cell Death & Disease, 2018 - nature.com
Leptin, produced and secreted by white adipose tissue, plays a critical role in regulating
body weight, food intake, and energy metabolism. Recently, several studies have identified …
body weight, food intake, and energy metabolism. Recently, several studies have identified …