Background: Although there is considerable evidence that patients with schizophrenia have
impaired executive functions, the neural mechanisms underlying these deficits are unclear …

BACKGROUND: We sought to determine if a representative group of young chronic patients
with schizophrenia would demonstrate selective impairments in set shifting processes of the …

Patients with schizophrenia have deficits in executive function that involve attentional set-
shifting and planning ability. It is unclear, however, whether such deficits are stable during …

BACKGROUND: Impairments of executive functioning, such as set-shifting ability, are seen
as core deficits of schizophrenia and are of interest as candidate intermediate phenotype …

Pervasive deficits of attention and set switching have been reported in schizophrenia,
prompting efforts to identify the information processing mechanisms associated with these …

Neuropsychological studies of patients with schizophrenia have consistently identified
deficits on tests sensitive to frontal lobe function. One paradigm that has been widely used is …

Difficulty switching behavioral response sets is established in psychotic disorders. In rodent
models, prefrontal lesions cause difficulty initially switching to new response sets …

BACKGROUND: Executive functioning refers to a set of processes involved in complex, goal-
directed thought and behavior involving multiple brain regions (eg, prefrontal cortex, parietal …

Task set maintenance and switching deficits are robust in schizophrenia. However, little is
known about how these constructs are related to one another. The development of an …

Addiction is a frequent comorbid disorder in schizophrenia related to dopaminergic
dysfunction in fronto-subcortical circuits. These brain networks are relevant for both …