Clonidine, like many other imidazoline drugs, is usually thought of as a selective α2-
adrenergic agonist and is approved for use as a centrally acting antihypertensive agent. In …

The cardiovascular relevance of imidazoline receptors (IR) has received tremendous
attention since their discovery in 1984. However, evidence also has accumulated for the …

Major depression, opioid addiction, neurodegenerative diseases, and glial tumors are
associated with disturbances of imidazoline receptors (IR) in the human brain. In …

Imidazoline receptors (IR), a novel family of non‐adrenergic receptors, are present in brain,
especially the limbic system, and platelets among other organs. Their functions include …

Background: A downregulation of I2-imidazoline binding sites has been reported in frontal
cortices of depressed suicide victims, according to I2-radioligand binding and confirmed by …

THE newly discovered imidazoline receptors have been found to be upregulated in patients
with major depression (platelet 45 kDa and 35 kDa proteins) and in suicide victims (brain 45 …

Background: Imidazoline receptors are a newly discovered family of receptors, some of
which, like α 2 adrenoceptors, have a presynaptic inhibitory effect on the release of …

A substantial number of studies have demonstrated increased imidazoline receptors (I1
binding sites) on platelets of depressed patients and downregulation following …

The literature on alpha 2-adrenoceptors in depression is replete with seemingly
contradictory findings, including reports of both hypersensitive and hyposensitive alterations …

[3H] RX821002,[3H] clonidine and [3H] idazoxan have previously been shown to selectively
label α2-adrenergic receptors, I1 and I2 imidazoline receptors in the human central nervous …