Catechol-O-methyltransferase val158met genotype determines effect of reboxetine on emotional memory in healthy male volunteers

AA Gibbs, CE Bautista, FD Mowlem, KH Naudts… - Journal of Psychiatry and …, 2014 - jpn.ca
Background: Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the
prefrontal cortex (PFC). A common polymorphism in the COMT gene (COMT val158met) has …

Catechol-O-methyltransferase activity does not influence emotional processing in men

MAG Martens, N Dalton, J Scaife… - Journal of …, 2022 - journals.sagepub.com
Background: Catechol-O-methyltransferase (COMT) regulates cortical dopaminergic
transmission and prefrontal-dependent cognitive function. However, its role in other …

Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex

MN Smolka, G Schumann, J Wrase… - Journal of …, 2005 - Soc Neuroscience
Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters
dopamine, epinephrine, and norepinephrine. A functional polymorphism in the COMT gene …

Differential effect of catechol-O-methyltransferase Val158Met genotype on emotional recognition abilities in healthy men and women

EM Weiss, E Stadelmann, CG Kohler… - Journal of the …, 2007 - cambridge.org
The catechol-O-methyltransferase (COMT) Val158Met polymorphism modulates executive
functions and working memory and recent neuroimaging studies implicate an association …

[HTML][HTML] COMT Val158Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition

SM Farrell, EM Tunbridge, S Braeutigam… - Biological psychiatry, 2012 - Elsevier
BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes dopamine. The COMT
Val158Met polymorphism influences its activity, and multiple neural correlates of this …

Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications

TW Weickert, TE Goldberg, A Mishara, JA Apud… - Biological …, 2004 - Elsevier
BACKGROUND: The gene encoding catechol-O-methyltransferase (COMT), an enzyme that
regulates prefrontal cortex dopamine, contains a common functional polymorphism …

Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation

EM Drabant, AR Hariri… - Archives of general …, 2006 - jamanetwork.com
Context CatecholO-methyltransferase (COMT), the major enzyme determining cortical
dopamine flux, has a common functional polymorphism (val 158 met) that affects prefrontal …

Effect of COMT val158met genotype on cognition and personality

AJ Sheldrick, A Krug, V Markov, D Leube… - European …, 2008 - cambridge.org
The gene encoding catechol-O-methyltransferase (COMT), an enzyme which regulates
prefrontal cortex dopamine, contains a common functional single nucleotide polymorphism …

Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy

S Anttila, K Huuhka, M Huuhka, A Illi, R Rontu… - The …, 2008 - nature.com
Several lines of evidence suggest that catechol-O-methyltransferase (COMT) may be
associated with treatment response in depression. We conducted a study on 119 patients …

The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks

A Heinz, MN Smolka - Reviews in the Neurosciences, 2006 - degruyter.com
SYNOPSIS Catechol-O-methyltransferase (COMT) degrades the catecholamine
neurotransmitters dopamine, epinephrine, and norepinephrine. A functional polymorphism …