Background: Synaptic dysfunction has been shown to be involved in the pathogenesis of
autism. We hypothesized that the protocadherin α gene cluster (PCDHA), which is involved …

Autism is a severe neurodevelopmental disorder of early childhood. Genetic factors play an
important role in the aetiology of the disorder. In this study, we considered the NRCAM gene …

Objective. Genetic factors play an important role in the development of autism spectrum
disorder (ASD). This case-control study was to determine the association between childhood …

Background Behavioral symptoms in individuals with autism spectrum disorder (ASD) have
been attributed to abnormal neuronal connectivity, but the molecular bases of these …

Synaptogenesis, the formation of functional synapses, is a crucial step for the development
of the central nervous system. Among the genes involved in this process are cell adhesion …

Results of recent genome-wide association studies (GWAS) and whole genome sequencing
(WGS) highlighted type II cadherins as risk genes for autism spectrum disorders (ASD). To …

Objectives. Neurotransmitter systems and neurotrophic factors can be considered strong
candidates for autism spectrum disorder (ASD). The serotoninergic and dopaminergic …

Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition
characterized by persistent deficits in social communication and interaction. Common …

Autism spectrum disorders (ASD) are a heterogeneous group of neuropsychiatric disorders
characterized by problems in social communication, as well as by the presence of restricted …

Autism spectrum disorder (ASD) is a highly heritable, complex disorder in which rare
variants contribute significantly to disease risk. Although many genes have been associated …