Objective: Previous studies have suggested that oxidative stress may play a role in the
pathophysiology of bipolar disorder (BD). Moreover, recent studies indicate that lithium and …

Objective: Recent studies have suggested that oxidative stress and DNA damage may play
a role in the pathophysiology of bipolar disorder (BD). We investigated the effects of the …

Mood stabilizing drugs lithium and valproate are the most commonly used treatments for
bipolar disorder. Previous studies in our laboratory indicate that chronic treatment with …

In this study, we assessed the oxidative stress parameters in rats submitted to an animal
model of mania induced by ouabain (OUA), which included the use of lithium (Li) and …

Studies have demonstrated that oxidative stress is associated with amphetamine-induced
neurotoxicity, but little is known about the adaptations of antioxidant enzymes in the brain …

Studies have proposed the involvement of oxidative stress and neuronal energy
dysfunctions in the pathophysiology of bipolar disorder (BD). This study evaluates plasma …

Background Several studies have described increased oxidative stress (OxS) parameters
and imbalance of antioxidant enzymes in Bipolar Disorder (BD) but few is know about the …

Objectives Several recent studies have suggested that the physiopathology of bipolar
disorder (BD) is related to immune system alterations and inflammation. Lithium (Li) is a …

Objectives The goal of the present study was to investigate the effects of lithium
administration on behavior, oxidative stress parameters and cytokine levels in the periphery …

Background: Acute mania can be modeled in animals using D‐amphetamine (AMPH). Acute
AMPH injections are associated with monoamine depletion, loss of neurofilaments and …