G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease
B Galet, M Ingallinesi, J Pegon, A Do Thi… - Journal of Psychiatry and …, 2021 - jpn.ca
Background In addition to motor disability, another characteristic feature of Parkinson
disease is the early appearance of psychiatric symptoms, including apathy, depression …
disease is the early appearance of psychiatric symptoms, including apathy, depression …
Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats
M Ingallinesi, L Le Bouil, N Faucon Biguet… - Molecular …, 2015 - nature.com
Gpr88, an orphan G-protein-coupled receptor, is highly and almost exclusively expressed in
the medium spiny projection neurons of the striatum, and may thus participate in the control …
the medium spiny projection neurons of the striatum, and may thus participate in the control …
[HTML][HTML] Knock-down of GPR88 in the dorsal striatum alters the response of medium spiny neurons to the loss of dopamine input and L-3-4-dyhydroxyphenylalanine
M Ingallinesi, B Galet, J Pegon… - Frontiers in …, 2019 - frontiersin.org
The effects of L-3-4-dyhydroxyphenylalanine (L-DOPA) treatment for replacing the
dopamine (DA) loss in Parkinson's disease (PD) progressively wear off and are hindered by …
dopamine (DA) loss in Parkinson's disease (PD) progressively wear off and are hindered by …
Mice lacking GPR88 show motor deficit, improved spatial learning, and low anxiety reversed by delta opioid antagonist
Background GPR88 is an orphan G protein coupled receptor highly enriched in the striatum,
and previous studies have focused on GPR88 function in striatal physiology. The receptor is …
and previous studies have focused on GPR88 function in striatal physiology. The receptor is …
Developmental and adult expression patterns of the G‐protein‐coupled receptor GPR88 in the rat: Establishment of a dual nuclear–cytoplasmic localization
R Massart, V Mignon, J Stanic… - Journal of …, 2016 - Wiley Online Library
ABSTRACT GPR88 is a neuronal cerebral orphan G‐protein‐coupled receptor (GPCR) that
has been linked to various psychiatric disorders. However, no extensive description of its …
has been linked to various psychiatric disorders. However, no extensive description of its …
Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents
R Massart, JP Guilloux, V Mignon… - European Journal of …, 2009 - Wiley Online Library
GPR88, an orphan G protein‐coupled receptor, was designated Strg/GPR88 for striatum‐
specific G protein‐coupled receptor (K. Mizushima et al.(2000) Genomics, 69, 314‐321). In …
specific G protein‐coupled receptor (K. Mizushima et al.(2000) Genomics, 69, 314‐321). In …
GPR55: A therapeutic target for Parkinson's disease?
M Celorrio, E Rojo-Bustamante, D Fernández-Suárez… - …, 2017 - Elsevier
The GPR55 receptor is expressed abundantly in the brain, especially in the striatum,
suggesting it might fulfill a role in motor function. Indeed, motor behavior is impaired in mice …
suggesting it might fulfill a role in motor function. Indeed, motor behavior is impaired in mice …
Lack of GPR88 enhances medium spiny neuron activity and alters motor-and cue-dependent behaviors
A Quintana, E Sanz, W Wang, GP Storey… - Nature …, 2012 - nature.com
The striatum regulates motor control, reward and learning. Abnormal function of striatal
GABAergic medium spiny neurons (MSNs) is believed to contribute to the deficits in these …
GABAergic medium spiny neurons (MSNs) is believed to contribute to the deficits in these …
The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?
In rodents, the orphan G protein-coupled receptor, Gpr88, is highly expressed in brain
regions implicated in the pathophysiology of and is modulated by treatments for …
regions implicated in the pathophysiology of and is modulated by treatments for …
Orphan GPR52 as an emerging neurotherapeutic target
GPR52 is a highly conserved, brain-enriched, G s/olf-coupled orphan G protein-coupled
receptor (GPCR) that controls various cyclic AMP (cAMP)-dependent physiological and …
receptor (GPCR) that controls various cyclic AMP (cAMP)-dependent physiological and …